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Bradykinin (1-5)
| Overview | |
|---|---|
| Description | The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. Bradykinin (1-5) may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for certain biological activities. BK 1-5 is the smallest peptide that can inhibit α-thrombin-induced platelet aggregation and secretion and calcium mobilization. Bradykinin (1-5) also prevents α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins. |
| Cas No | 23815-89-6 |
| Sequence | {ARG}{PRO}{PRO}{GLY}{PHE} |
| Sequence Shortening | RPPGF |
| Molecular Formula | C27H40N8O6 |
| Molecular Weight | 572.66 |
| Properties | |
| Purity | > 95% |
| Gmp Flag | 0 |
| Storage | Store the peptide at -20°C |
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