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Galanin Receptor Ligand M35
| Overview | |
|---|---|
| Description | The chimeric peptide M35 [galanin (1-13)-bradykinin(2-9) amide] is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic islets. The radiolabelled M35 and performed equilibrium binding studies with [125I] M35 on the rat pancreatic beta-cell line Rin m 5F. Galanin displaces [125I] M35 with the same affinity (KD = 1 nM) as it displaces [125I] galanin. Displacement of [125I] galanin by M35 from Rin m 5F cell membranes shows the presence of two binding sites for M35 with KD-values of 0.3 +/- 0.1 nM and 0.52 +/- 0.03 µM, respectively. |
| Sequence | {GLY}{TRP}{THR}{LEU}{ASN}{SER}{ALA}{GLY}{TYR}{LEU}{LEU}{GLY}{PRO}{PRO}{PRO}{GLY}{PHE}{SER}{PRO}{PHE}{ARG}-NH2 |
| Sequence Shortening | GWTLNSAGYLLGPPPGFSPFR-NH2 |
| Molecular Formula | C107H153N27O26 |
| C Terminal | NH2 |
| Molecular Weight | 2233.6 |
| Properties | |
| Purity | > 95% |
| Solubility | Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents. |
| Gmp Flag | 0 |
| Storage | Store at -20°C |
About InnoPep
InnoPep Inc. is a company started by a couple of researchers with decades of expertise in peptide synthesis and conjugation aimed at enabling.