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Orexin B, human
| Overview | |
|---|---|
| Description | Orexin B is a hypothalamatic neuropeptide stimulating food intake in rats. Orexin B activates OX2 receptors. Both OX1 and OX2 receptors are involved in maintaining arousal. OX2 receptors appear to be inhibitory autoreceptors on orexin-containing neurons. Orexin B stimulates food consumption in a similar manner to orexin A, but the effect did not last as long as that of orexin A. The affinity of orexin B for the OX1 receptor is significantly lower than that of orexin A. Binding affinities for the OX2 receptor are similar for orexin A and B. |
| Sequence | {ARG}{SER}{GLY}{PRO}{PRO}{GLY}{LEU}{GLN}{GLY}{ARG}{LEU}{GLN}{ARG}{LEU}{LEU}{GLN}{ALA}{SER}{GLY}{ASN}{HIS}{ALA}{ALA}{GLY}{ILE}{LEU}{THR}{MET}-NH2 |
| Sequence Shortening | RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2 |
| Molecular Formula | C123H212N44O35S1 |
| C Terminal | NH2 |
| Molecular Weight | 2899.34 |
| Properties | |
| Purity | > 95% |
| Solubility | Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents. |
| Gmp Flag | 0 |
| Storage | Store at -20°C. |
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