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Product Code: 3271-0100

Price: $187.00

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Description This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.
Sequence NF-(NMe-G)-A-(NMe-I)-L
Sequence (3 Letter) H - Asn - Phe - (NMe - Gly) - Ala - (NMe - Ile) - Leu - OH
Molecular Weight 661.8
Purity % Peak Area By HPLC ≥ 95%
Storage -20 °C
Yan, L. et al. PNAS 103, 2046 (2006), Kapurniotu, A., et al. J. Mol. Biol. 315, 339 (2002), Tatarek-Nossol, M. et al. Cell Press 12, 797 (2005).

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