![[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22 - 27)<br>NF - (NMe - G) - A - (NMe - I) - L](/media/com_eshop/products/resized/prod_150x150-500x500.png "[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22 - 27)<br>NF - (NMe - G) - A - (NMe - I) - L")
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[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22 - 27)
NF - (NMe - G) - A - (NMe - I) - L
| Overview | |
|---|---|
| Description | This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis. |
| Sequence | NF-(NMe-G)-A-(NMe-I)-L |
| Sequence (3 Letter) | H - Asn - Phe - (NMe - Gly) - Ala - (NMe - Ile) - Leu - OH |
| Molecular Weight | 661.8 |
| Properties | |
| Purity | % Peak Area By HPLC ≥ 95% |
| Storage | -20 °C |
Yan, L. et al. PNAS 103, 2046 (2006), Kapurniotu, A., et al. J. Mol. Biol. 315, 339 (2002), Tatarek-Nossol, M. et al. Cell Press 12, 797 (2005).
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