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Bid BH3 - r8
| Overview | |
|---|---|
| Description | The Bid BH3 is a pro-apoptotic member of the "BH3-only" subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide. |
| Sequence | rrrrrrrr-GEDIIRNIARHLAQVGDSMDR |
| Sequence (3 Letter) | H-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-Gly-Glu-Asp-Ile-Ile-Arg-Asn-Ile-Ala-Arg-His-Leu-Ala-Gln-Val-Gly-Asp-Ser-Met-Asp-Arg |
| Molecular Weight | 3616.2 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Letai, A. J.Clin. Invest. 115, 2648 (2005); Mendoza, F. et al. Arch. Immunol. Ther. Exp. 53, 47 (2002).
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InnoPep Inc. is a company started by a couple of researchers with decades of expertise in peptide synthesis and conjugation aimed at enabling.