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Neuropilin - 1 (NRP - 1) Antagonist; EG3287
| Overview | |
|---|---|
| Description | This is EG3287, a peptide fragment based on the Neuropilin-1 (NRP-1) Vascular Endothelial Growth Factor A (VEGF-A) binding site, located on exons 7 and 8. EG3287 is a NRP-1 antagonist and contains an C-terminal Arg essential for inhibition of VEGF165 binding. As a result, EG3287 decreases tumor angiogenesis and growth. |
| Sequence | SCKNTDSRCKARQLELNERTCRCDKPRR (Disulfide bridge 2-20 and 9-22) |
| Sequence (3 Letter) | H-Ser-Cys-Lys-Asn-Thr-Asp-Ser-Arg-Cys-Lys-Ala-Arg-Gln-Leu-Glu-Leu-Asn-Glu-Arg-Thr-Cys-Arg-Cys-Asp-Lys-Pro-Arg-Arg-OH (Disulfide bridge 2-20 and 9-22) |
| Molecular Weight | 3363.9 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
D'Andrea, LD. et al. Curr Pharm Des 15, 2414 (2009); Starzec, A. et al. Peptides 28, 2397 (2007).
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