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PRAME epitope (PRA300 - 309) Tumor - associated antigen
| Overview | |
|---|---|
| Description | PRAME (Preferentially Expressed Antigen of Melanoma), first isolated as a human melanoma antigen recognized by cytotoxic T cells (CTL), is frequently expressed in a variety of cancers. The PRAME gene can be detected in some of the hematological malignancies, neuroblastomas and normal testis. PRAME is a promising marker for detection of minimal residual disease (MRD) in patients with leukemia and a particularly attractive target for immunotherapeutic strategies in neuroblastoma. |
| Sequence | ALYVDSLFFL |
| Sequence (3 Letter) | H-Ala-Leu-Tyr-Val-Asp-Ser-Leu-Phe-Phe-Leu-OH |
| Molecular Weight | 1187.4 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Ref: Matsushita, M. et al. Leuk. Lymphoma 44, 439 (2003); Kessler, J. et al. J. Exp. Med. 193, 73 (2001).
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