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RGD - targeted Proapoptotic Peptide
| Overview | |
|---|---|
| Description | This sequence is a targeted proapoptotic peptide. The C-terminal RGD-4C peptide (ACDCRGDCFC) binds preferentially to integrins at sites of tumor angiogenesis. Two glycines provide spacer, and D(KLAKLAK)2 is the proapoptotic peptide composed of D-amino acids. |
| Sequence | ACDCRGDCFC-GG-klaklakklaklak-NH2 (disulfide bridge: C1-C4 & C2-C3) |
| Sequence (3 Letter) | H-Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly-Gly-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-NH2 (S-S bonded C1-C4 & C2-C3) |
| Molecular Weight | 2707.4 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Lahdenranta, J. et al. FASEB J. 10.1096/fj.07-8273com (2007); Ellerby, H. et al. Nat. Med. 5, 1032 (1999); Smolarczyk, R. et al. Acta Biochim. Pol. 53, 801 (2006); Curnis, F. et al. Cancer Res. 64, 565 (2004); Su, Z. et al. Bioconjug. Chem. 13, 561 (2002).
About InnoPep
InnoPep Inc. is a company started by a couple of researchers with decades of expertise in peptide synthesis and conjugation aimed at enabling.