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Product Code: 3165-0100

Price: $136.00

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Description Programed cell death protein 1 (PD-1) is a cell surface receptor. PD-1 and its ligand PD-L1 are crucial immune checkpoints to downregulate T cell activation, tolerance and immunopathology. Several types of cancer cells overexpress PD-L1 in order to escape from the PD-1/PD-L1 immunosurveillance mechanism. Human PD-L1 inhibitor II is a peptide-based molecule. It binds to human PD-1 and inhibits PD-1/PD-L1 binding. This peptide, PDL-1 inhibitor I has anchor residues, WDY that influence binding of hPD-L1 to hPD-1. Developing inhibitors specifically blocking the PD-1/PD-L1 pathway has become a popular approach toward cancer treatment.PD-L1 Related Peptides:Human PD-L1 inhibitor I, Cat# AS-65581Human PD-L1 inhibitor III, Cat# AS-65583Human PD-L1 inhibitor IV, Cat# AS-65584Human PD-L1 inhibitor V, Cat# AS-65585
Sequence (3 Letter) H - Phe - Asn - Trp - Asp - Tyr - Ser - Leu - Glu - Glu - Leu - Arg - Glu - Lys - Ala - Lys - Tyr - Lys - OH
Molecular Weight 2219.6
Purity % Peak Area By HPLC ≥ 95%
Storage -20 °C
Bardhan K.,, Front Immunol 7(550), (2016); Li Q.,, Oncotarget 7(40), 64967-64976 (2016); D'Errico G.,, Clin Transl Med 6(1), 3-12 (2017)

About InnoPep

InnoPep Inc. is a company started by a couple of researchers with decades of expertise in peptide synthesis and conjugation aimed at enabling.

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