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InnoPep Gamma - Fibrinogen (377 - 395)
YSMKETTMKIIPFNRLSIG
YSMKETTMKIIPFNRLSIG.. Product #: 3433-0100 Regular price: $101.00 $101.00

Gamma - Fibrinogen (377 - 395)
YSMKETTMKIIPFNRLSIG

Product Code: 3433-0100
Weight: 1.00mg

Price: $101.00

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This fibrinogen-derived inhibitory peptide attenuates microglia activation and suppresses relapsing paralysis in multiple sclerosis (MS). Fibrinogen is a regulator of microglia activation and interaction of fibrinogen with the microglia integrin receptor Mac-1. Because blocking fibrinogen–Mac-1 interactions affects the pro-inflammatory but not the pro-coagulant properties of fibrinogen, targeting this gamma- fibrinogen epitope could represent a potential therapeutic strategy for MS and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation.

Adams, R. et al. J. Exp. Med. Published online 5 March 2007 doi:10.1084/jem.20061931
Chemistry
Purity % Peak Area By HPLC ≥ 95%
Molecular Weight 2229.7
Sequence YSMKETTMKIIPFNRLSIG
Sequence (3 Letter) H - Tyr - Ser - Met - Lys - Glu - Thr - Thr - Met - Lys - Ile - Ile - Pro - Phe - Asn - Arg - Leu - Ser - Ile - Gly - OH
Biology
Storage -20°C

About InnoPep

InnoPep Inc. is a company started by a couple of researchers with decades of expertise in peptide synthesis and conjugation aimed at enabling.

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