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Neuropeptide S, NPS (1 - 10), rat
| Overview | |
|---|---|
| Description | This is amino acids 1 to 10 fragment of rat neuropeptide S, rNPS, the endogenous ligand of an orphan G protein-coupled receptor (GPCR). Central administration of NPS promotes behavioral arousal and suppresses all stages of sleep in rodents. NPS may induce transient increases of intracellular Ca2+, indicating that it might have excitatory effects at the cellular level. NPS receptor can couple to intracellular Ca2+. The pharmacophore of NPS is contained within the N-terminal part of the peptide, and NPS 1 to 10 is a minimally active structure. |
| Sequence | SFRNGVGSGV |
| Sequence (3 Letter) | H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Val-OH |
| Molecular Weight | 979.1 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Reinscheid, R. et al. J. Pharmacol. Exp. Ther. 315, 1338 (2005).
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