![[Arg(Me2a)2, Lys(Ac)4] - Histone H3 (1 - 21) - GGK(Biotin)](/media/com_eshop/products/resized/prod_150x150-500x500.png "[Arg(Me2a)2, Lys(Ac)4] - Histone H3 (1 - 21) - GGK(Biotin)")
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[Arg(Me2a)2, Lys(Ac)4] - Histone H3 (1 - 21) - GGK(Biotin)
| Overview | |
|---|---|
| Description | This peptide is histone H3 (1-21) with asymmetrical dimethylation at Arg2, and acetylation at Lys4, followed by a C-terminal GGK with biotinylation on the side chain of Lys. Asymmetrical dimethylation of Arg2 typically inhibits Lys4 methylation and is associated with transcriptional silencing. Lys4 acetylation acts as a chromodomain switch by weakening the interaction between Chp1 and the H3K9 methylated tail, thus facilitating binding of HP1 proteins. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form. |
| Sequence | A-R(Me2a)-T-K(Ac)-QTARKSTGGKAPRKQLAGG-K(Biotin) |
| Sequence (3 Letter) | H-Ala-Arg(Me2a)-Thr-Lys(Ac)-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Gly-Gly-Lys(Biotin)-OH |
| Molecular Weight | 2793.3 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Xhemalce, B. and T. Kouzarides. Gene Dev 24, 647 (2010); Klose, R. and Y. Zhang. Nat Struct Mol Biol 14, 1058 (2007); Garcia, B. et al. J Biol Chem 282, 7641 (2007).
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