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Histone 4 - 12, p300/CBP Substrate
| Overview | |
|---|---|
| Description | This 12 residues long fragment (amino acids 3 to14) of the histone 4, is also known as H4-12. Histone acetyltransferase (HAT) p300/CBP catalyzes the acetylation of this N-terminal tail of free histone H4 at Lys5, 8, 12. Lys8 is thought to be the preferred acetylation site in H4. Determinants of interaction of p300 with histone 4 appear to be fully present on H4-12, the N-terminal region of the protein. H4-12. is functionally equal to the longer H4-21 peptide, despite the loss of nine amino acids. |
| Sequence | RGKGGKGLGKGA |
| Sequence (3 Letter) | H-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Ala-OH |
| Molecular Weight | 1085.3 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Thompson, P. et al. J. Biol. Chem. 276, 33721 (2001).
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