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Insulin B (9 - 23)
SHLVEALYLVCGERG
| Overview | |
|---|---|
| Description | This insulin B-chain peptide binds to a class II histocompatibility complex (MHC) allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic ß cells leading to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunization with this peptide in mice led to autoantibodies and insulitis. |
| Sequence | SHLVEALYLVCGERG |
| Sequence (3 Letter) | H - Ser - His - Leu - Val - Glu - Ala - Leu - Tyr - Leu - Val - Cys - Gly - Glu - Arg - Gly - OH |
| Molecular Weight | 1645.9 |
| Properties | |
| Purity | % Peak Area By HPLC ≥ 95% |
| Storage | -20 °C |
Devendra, D. et al. Diabetes 54, 2549 (2005). Starwalt, S. et al. Protein Eng. 16, 147 (2003); Lee, L. et al. PNAS 102, 15995 (2005).
About InnoPep
InnoPep Inc. is a company started by a couple of researchers with decades of expertise in peptide synthesis and conjugation aimed at enabling.