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Pannexin - 1 (Panx1), Mimetic Blocking Peptide
WRQAAFVDSY
| Overview | |
|---|---|
| Description | This is a Pannexin-1 (Panx1) mimetic blocking peptide. Pannexin-1 is a recently identified membrane protein that can form gap junction-like connections allowing intercellular passage of dyes when overexpressed in two adjacent oocytes or mammalian epithelial cell lines. Blockade of pannexin-1 in macrophage endogenously expressing the ATP-gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1? (IL-1?) in response to P2X7R activation. |
| Sequence | WRQAAFVDSY |
| Sequence (3 Letter) | H - Trp - Arg - Gln - Ala - Ala - Phe - Val - Asp - Ser - Tyr - OH |
| Molecular Weight | 1242.4 |
| Properties | |
| Purity | % Peak Area By HPLC ≥ 95% |
| Storage | -20 °C |
Pelegrin, P. et al. EMBO. J. 25, 5071 (2006); Pelegrin, P. et al.t J. Biol. Chem. 282, 2386 (2007).
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