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Apamin
| Overview | |
|---|---|
| Description | Apamin, a bee venom polypeptide, blocks specifically the Ca2+-dependent K+ channels that are not blocked by tetraethylammonium chloride in muscle cells. Apamin is a highly specific compound that tightly binds to the Ca2+ slow channels, thus blocking the slow APs in heart muscle. In addition, quinidine antagonizes the apamin binding on the slow APs. |
| Cas No | 24345-16-2 |
| Sequence | {CYS}{ASN}{CYS}{LYS}{ALA}{PRO}{GLU}{THR}{ALA}{LEU}{CYS}{ALA}{ARG}{ARG}{CYS}{GLN}{GLN}{HIS}-NH2 |
| Sequence Shortening | CNCKAPETALCARRCQQH-NH2 |
| Molecular Formula | C79H131N31O24S4 |
| C Terminal | NH2 |
| Disulfide Bridge | Disulfide Bridge Cys1-Cys11 and Cys3-Cys15 |
| Molecular Weight | 2027.3 |
| Properties | |
| Purity | > 95% |
| Format Bridge | 1-11,3-15 |
| Gmp Flag | 0 |
| Storage | Store at -20°C. Keep tightly closed. Store in a cool dry place. |
| Note | Originally isolated from Apis mellifera. A small conductance Ca2+-activated K+ channel blocker. |
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