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Bax BH3 peptide (55 - 74), wild type
| Overview | |
|---|---|
| Description | This is a 20 €“amino acid Bax BH3 peptide (Bax 1) capable of inducing apoptosis in a variety of cell line models. In addition to disrupting Bax/Bcl-2 and Bax/Bcl-XL, it can promote cytochrome c release from isolated mitochondria. Bax BH3 belongs to the Bcl-2 protein family which consists of both pro-apoptotic and anti-apoptotic members. Bax BH3 acts to regulate apoptosis via governance of the "intrinsic" pathway of cell death. |
| Sequence | STKKLSECLKRIGDELDSNM |
| Sequence (3 Letter) | H-Ser-Thr-Lys-Lys-Leu-Ser-Glu-Cys-Leu-Lys-Arg-Ile-Gly-Asp-Glu-Leu-Asp-Ser-Asn-Met-OH |
| Molecular Weight | 2267.6 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Shangary, S. et al. Mol. Canc. Ther. 3, 1343 (2004); Shangary, S. et al. Biochem. 41, 9485 (2002).
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