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LyP - 1, Peptide 1
| Overview | |
|---|---|
| Description | LyP-1 recognizes lymphatics and tumor cells in certain tumors, but not lymphatics in normal tissues. Screening on breast carcinoma xenografts shows positive to cyclic 9-amino-acid peptide, LyP-1. The LyP-1 also recognizes an osteosarcoma xenograft, and spontaneous prostate and breast cancers in transgenic mice. LyP-1 peptide is detected in tumor structures that are positive for several lymphatic endothelial markers and negative for blood vessel markers. LyP-1 accumulates in the nuclei of the putative lymphatic cells, and in the nuclei of tumor cells. |
| Sequence | CGNKRTRGC (S-S Bonded) |
| Sequence (3 Letter) | H-Cys-Gly-Asn-Lys-Arg-Thr-Arg-Gly-Cys-OH (S-S Bonded) |
| Molecular Weight | 992.2 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Zhang, L. et al. Canc. Res. 66, 5696 (2006); Akerman, M. et al. PNAS 99, 12617 (2002); Laakkonen, P.et al. Nat. Med. 8, 751 (2002).
About InnoPep
InnoPep Inc. is a company started by a couple of researchers with decades of expertise in peptide synthesis and conjugation aimed at enabling.