Call Now: +1 858 800 3101 Email: info@innopep.com


Your shopping cart is empty!

InnoPep Products Filter

InnoPep Caspase 3 (Apopain) Substrate 1, chromogenic
Ac - DEVD - pNA
Ac-DEVD-pNA.. Product #: 3037-0500 Regular price: $73.00 $73.00

Caspase 3 (Apopain) Substrate 1, chromogenic
Ac - DEVD - pNA

Product Code: 3037-0500
Weight: 5.00mg

Price: $73.00

Available Options

* Package Size:

pNA (4-nitroaniline)-derived caspase substrates are widely used for the colorimetric detection of various caspase activities. Cleavage of pNA peptides by caspases generates pNA that is monitored colorimetrically at ~405 nm. pNA has maximum absorption around 408 nm.Caspase-1 substrate with Km = 18 uM and kcat = 0.5 M-1s-1; Caspase-3 substrate with Km = 11 uM and kcat = 2.4 M-1s-1;Caspase-4 substrate with Km = 32 uM and kcat = 0.05 M-1s-1 Caspase-6 substrate with Km = 180 uM and kcat = 0.6 M-1s-1 ; Caspase-7 substrate with Km = 12 uM and kcat = 0.4 M-1s-1; Caspase-8 substrate with Km = 167 uM

Grutter MG (2000). Caspases: key players in programmed cell death. Curr Opin Struct Biol 10, 649-55; Gastman BR (2001). Apoptosis and its clinical impact. Head Neck 23, 409-25; Grutter MG (2000). Caspases: key players in programmed cell death. Curr Opin Struct Biol 10, 649-55; Stennicke HR and Salvesen GS (1999). Catalytic properties of the caspases. Cell Death Differ 6, 1054-9; Stennicke HR and Salvesen GS (1998). Properties of the caspases. Biochim Biophys Acta 1387, 17-31; Thornberry NA and Lazebnik Y (1998). Caspases: enemies within. Science 281, 1312-6; Talanian RV, et al. (1997). Substrate specificities of caspase family proteases. J Biol Chem 272, 9677-82; Fassy F, et al. (1998). Enzymatic activity of two caspases related to interleukin-1beta-converting enzyme. Eur J Biochem 253, 76-83; Datta R, et al. (1996). Activation of the CPP32 protease in apoptosis induced by 1-?-D-arabinofuranosylcytosine and other DNA-damaging agents. Blood 88, 1936-43; Koeplinger KA, et al. (2000). Caspase 8: an efficient method for large-scale autoactivation of recombinant procaspase 8 by matrix adsorption and characterization of the active enzyme. Protein Expr Purif 18, 378-87.
Chemistry
Purity % Peak Area By HPLC ≥ 95%
Molecular Weight 638.5
Sequence Ac-DEVD-pNA
Sequence (3 Letter) Ac - Asp - Glu - Val - Asp - pNA
Biology
Storage -20°C desiccated and protected from light

About InnoPep

InnoPep Inc. is a company started by a couple of researchers with decades of expertise in peptide synthesis and conjugation aimed at enabling.

Newsletter Signup

Stay Updated With Our Latest Products.

Your email is safe with us, we don't spam.