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Glutamic Acid Decarboxylase (GAD65) (524 - 543), p524 - 543
SRLSKVAPVIKARMMEYGTT
| Overview | |
|---|---|
| Description | This is amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). It is one of the first fragments of this islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. This peptide is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with p524 €“543 increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells. |
| Sequence | SRLSKVAPVIKARMMEYGTT |
| Sequence (3 Letter) | H - Ser - Arg - Leu - Ser - Lys - Val - Ala - Pro - Val - Ile - Lys - Ala - Arg - Met - Met - Glu - Tyr - Gly - Thr - Thr - OH |
| Molecular Weight | 2238.7 |
| Properties | |
| Purity | % Peak Area By HPLC ≥ 95% |
| Storage | -20 °C |
Quinn, A. et al. J. Immunol. 166, 2982 (2001); Dai, Y. et al. J. Immunol. 175, 3621 (2005).
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