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Beta - Amyloid (1 - 16)
| Overview | |
|---|---|
| Description | Proteins interactions with reactive oxygen agents may result in covalent modifications of amino acid residues in proteins, formation of protein-protein cross-linkages and oxidation of the protein backbone resulting in protein fragmentation. Oxidation targets for Aß (1-16) are the histidine residues coordinated to the metal ions. Copper is bound to Aß in senile plaque of Alzheimer €™s disease with Aß (1-16) taking part in the coordination of the Cu2+ ions. Cu2+ and Zn2+ are linked with the neurotoxicity of Aß and free radical damage. |
| Sequence | DAEFRHDSGYEVHHQK |
| Sequence (3 Letter) | H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-OH |
| Molecular Weight | 1955 |
| Properties | |
| Purity | > 95% By HPLC |
| Storage | Store at -20 °C, cap vial tightly at all times. |
Da Silva, GFZ. et al. J. Biol. Chem. 280, 16601 (2005); Kowalik-Jankowska, T. et al. J. Inorg. Biochem. 98, 940 (2004); Kowalik-Jankowska, T. et al. J. Inorg. Biochem. 95, 270 (2003).
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